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KMID : 1130320090520010056
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Korean Journal of Pediatrics
2009 Volume.52 No. 1 p.56 ~ p.60
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Rotavirus-associated neonatal necrotizing enterocolitis
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Seo Hyun-Joo
Jung Yu-Jin
Park Soo-Kyung
Choi Seo-Hui
Lee Ji-Hyuk
Kim Myo-Jing
Chang Yun-Sil
Park Won-Soon
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Abstract
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Purpose: This study aimed to test whether rotavirus-associated necrotizing enterocolitis (RV+NEC) produced different clinical findings or outcomes from those of non-rotavirus necrotizing enterocolitis (RV-NEC).
Methods: Eight patients from the RV+NEC group and 22 patients from the RV-NEC group diagnosed with modified Bell stage II or higher NEC were selected for this study. Fecal specimens from all infants were tested for rotavirus infection using a monoclonal antibody-based enzyme immunoassay (EIA). Clinical, radiographic, and clinical outcome data were analyzed retrospectively.
Results: RV+NEC infants had a significantly higher birth weight and were born at a significantly higher gestational age (33.5±3.3 weeks vs. 29.3±4.4 weeks; P=0.01). There were no differences in the occurrence of thrombocytopenia, mural gas, and pneumoperitoneum between the 2 groups. However, portal vein gas was more common in the RV+NEC group (88% vs. 9%; P<0.01). Neither the incidence of Bell stage III (or higher) NEC nor surgical intervention differed between the two groups. The number of complications and mortality rates were also similar.
Conclusion: Rotavirus-associated NEC occurs in infants with a higher birth weight and those born at a greater gestational age. However, the severity of the condition and the resulting outcomes did not differ from those for infants affected by non-rotavirus NEC.
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KEYWORD
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Rotavirus infections, Enterocolitis, Necrotizing, Newborn
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